2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. HIF/HIF Prolyl-Hydroxylase
  5. HIF/HIF Prolyl-Hydroxylase Modulator

HIF/HIF Prolyl-Hydroxylase Modulator

HIF/HIF Prolyl-Hydroxylase Isoform Comparison

HIF/HIF Prolyl-Hydroxylase Modulators (2):

Cat. No. Product Name Effect Purity
  • HY-19621
    THS-044
    		Modulator 99.67%
    THS-044 is a modulator of the formation of the HIF2α/ARNT heterodimer. THS-044 binding stabilizes the HIF2α PAS-B folded state (KD = 2 μM), for regulating HIF2 activity in endogenous and pathological settings, and does not bind to HIF1α or ARNT PAS-B. THS-044 increases the KD of the heterodimer formed by HIF2α PAS-B and ARNT PAS-B from 120 μM to 400 μM. THS-044 can be used for the study of diseases related to hypoxia.
  • HY-N6905
    Acetylarenobufagin
    		Modulator 98.63%
    Acetylarenobufagin is a steroidal hypoxia inducible factor-1 (HIF-I) modulator.